MMP9 −1562 C/T POLİMORFİZMİ, TÜRK TİP 2 DİABETES MELLİTUS HASTALARINDA ARTMIŞ DİYABETİK RETİNOPATİ RİSKİ İLE İLİŞKİLİDİR

Objective
 Type 2 diabetes mellitus (T2DM) and diabetic
 retinopathy (DR) development is affected by genetic
 factors. Matrix metalloproteinases (MMPs) are involved
 in many cellular processes, such as remodeling of
 extracellular matrix proteins angiogenesis. In
 this study, we investigated the relationship between
 MMP9 −1562 C/T (rs3918242) polymorphism the
 of T2DM DR Turkish population.
 Material Method
 A total 510 participants, involving 168 T2DM
 cases with DR, without DR,
 174 controls, were included study. The
 polymerase chain reaction-restriction fragment length
 (PCR-RFLP) method was carried out
 to identify genotypes.
 Results
 The CT, CT+TT genotypes T allele associated with
 increased risk (p=0.001). On other hand,
 no found between development
 polymorphism. In addition,
 CT (p=0.010) (p=0.015) genotype
 frequencies be higher proliferative
 diabetic (PDR) compared nonproliferative
 (NPDR) cases, but
 after regression analysis, only insulin use (p=0.003)
 PDR.
 Conclusion
 Our data show that polymorphism
 Turkish
 patients, but significant was
 severity T2DM.